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how to shrink a cystic pimple overnight, While it's challenging to get rid of a cystic pimple overnight, you can reduce its size and redness. Try applying a warm compress for 15-20 minutes to encourage drainage, followed by an over-the-counter cortisone cream to reduce inflammation. Avoid picking or squeezing the pimple, as this can worsen the situation. For faster results, consult a dermatologist for professional treatment options.